Parental translocations and the need for PGD? Distorting effects of ascertainment bias and the need for information-rich families.

Abstract

prognosis of recurrent aborters with either maternal or paternal reciprocal translocations. Fertil Steril 2004;81:367–73. 3. Goddijn M, Joosten JHK, Knegt AC, van derVeen F, Franssen MTM, Bonsel GJ, et al. Clinical relevance of diagnosing structural chromosome abnormalities in couples with repeated miscarriage. Hum Reprod 2004;19:1013–7. 4. Stephenson MD, Sierra S. Reproductive outcomes in recurrent pregnancy loss associated with a parental carrier of a structural chromosome rearrangement. Hum Reprod 2006;21:1076–82. 5. Munne S, Sandalinas M, Escudero T, Fung J, Gianaroli L, Cohen J. Saint Barnabas Medical Center PGD Network. Outcome of preimplantation genetic diagnosis of translocations. Fertil Steril 2000;73:1209–18. 6. Verlinsky V, tur-Kaspa I,Cieslak J, Bernal A, Morris R, Taranissi M, et al. Preimplantation testing for chromosomal disorders improves reproductive outcome of poor-prognosis patients. Reprod BioMed Online 2005;11:219–25.

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